New light-based method enables single-particle quality control in nanocrystal manufacturing

On July 12, 2026, researchers from Ludwig Maximilian University of Munich unveiled a groundbreaking method for achieving single-particle quality control in nanocrystal manufacturing. This innovation addresses the inherent heterogeneity of nanocrystals, which are essential for advanced technologies like quantum computing and solar energy.

Understanding Nanocrystal Heterogeneity

Nanocrystals are utilized in millions of devices, including televisions and laptops. However, their potential has not been fully realized due to their varying properties within a single solution. Professor Emiliano Cortés from LMU's Nano-Institute highlights that average values of properties are insufficient for effective device performance. “Each individual nanoparticle can behave differently—for example, in its size or in how efficiently it emits light,” he stated.

The new study published in Nature Materials reveals how researchers can now determine the size and quantum yield of thousands of individual perovskite nanocubes directly in solution. This approach allows for a more precise understanding of how each particle contributes to overall performance.

Advancements in Quality Control Techniques

The research team developed a light-based high-throughput method that enables quality control at the single-particle level. Dr. Christoph Gruber, the first author of the study, explained, “This is crucial for the reliable production of materials and the devices built from them.” By moving away from average values, researchers can now assess the variability of individual particles within a sample.

The perovskite nanocrystals, which measure under 20 nanometers, exhibit significant differences in optical performance. Professor Alexander Urban, who specializes in the synthesis of these nanocrystals, noted, “Smaller nanocrystals show a higher quantum yield—meaning they emit light more efficiently—than larger ones.” This discovery is vital for enhancing the performance of optoelectronic devices.

Challenges and Future Implications

Achieving high-throughput screening posed numerous technical challenges, particularly in handling large data volumes and ensuring the accuracy of measurements. Dr. Andrea Mancini, co-first author, emphasized the importance of stable in situ measurements to prevent degradation during analysis. “Achieving stable measurements was a major breakthrough,” Cortés added.

The patented method has attracted attention for its potential commercial applications, supported by a grant of €2.45 million. As part of the iNSyT One project, Gruber aims to develop this technology into a market-ready product, enabling rapid quality control of nanoparticles before their integration into devices.